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1

Telmisartan protects against cognitive decline via up-regulation of brain-derived neurotrophic factor/tropomyosin-related kinase B in hippocampus of hypertensive rats

Kishi, Takuya, Hirooka, Yoshitaka, Sunagawa, Kenji

Journal:

Journal of Cardiology

Year:

2012

Language:

english

File:

PDF, 354 KB

english, 2012

2

Cilnidipine Inhibits the Sympathetic Nerve Activity and Improves Baroreflex Sensitivity in Patients with Hypertension

Kishi, Takuya, Hirooka, Yoshitaka, Konno, Satomi, Sunagawa, Kenji

Journal:

Clinical and Experimental Hypertension

Year:

2009

Language:

english

File:

PDF, 104 KB

english, 2009

3

Effects of combination of whey protein intake and rehabilitation on muscle strength and daily movements in patients with hip fracture in the early postoperative period

Niitsu, Masaya, Ichinose, Daisuke, Hirooka, Taku, Mitsutomi, Kazuhiko, Morimoto, Yoshitaka, Sarukawa, Junichiro, Nishikino, Shoichi, Yamauchi, Katsuya, Yamazaki, Kaoru

Journal:

Clinical Nutrition

Year:

2015

Language:

english

File:

PDF, 1.06 MB

english, 2015

4

Olmesartan combined with renal denervation reduces blood pressure in association with sympatho-inhibitory and aldosterone-reducing effects in hypertensive mice with chronic kidney disease

Nishihara, Masaaki, Takesue, Ko, Hirooka, Yoshitaka

Journal:

Clinical and Experimental Hypertension

Year:

2018

Language:

english

File:

PDF, 1.06 MB

english, 2018

5

High central blood pressure is associated with incident cardiovascular events in treated hypertensives: the ABC-J II Study

Eguchi, Kazuo, Miyashita, Hiroshi, Takenaka, Tsuneo, Tabara, Yasuharu, Tomiyama, Hirofumi, Dohi, Yasuaki, Hashimoto, Junichiro, Ohkubo, Takayoshi, Ohta, Yuko, Hirooka, Yoshitaka, Kohara, Katsuhiko, It

Journal:

Hypertension Research

Year:

2018

Language:

english

File:

PDF, 625 KB

english, 2018

6

Different effects of α-human atrial natriuretic peptide and nitroglycerin on cardiac dimensions in humans

Tsutomu Imaizumi, Akira Takeshita, Megumu Yoshida, Satoshi Suzuki, Shin-ichi Ando, Yoshitaka Hirooka, Motoomi Nakamura

Journal:

Heart and Vessels

Year:

1990

Language:

english

File:

PDF, 604 KB

english, 1990

7

Impaired forearm vasodilatation by acetylcholine in patients with hypertension

Megumu Yoshida, Tsutomu Imaizumi, Shin-ichi Ando, Yoshitaka Hirooka, Seiki Harada, Akira Takeshita

Journal:

Heart and Vessels

Year:

1991

Language:

english

File:

PDF, 728 KB

english, 1991

8

Effects of a mental task on splanchnic blood flow in fasting and postprandial conditions

Nami Someya, Masako Yamaoka Endo, Yoshiyuki Fukuba, Yoshitaka Hirooka, Naoyuki Hayashi

Journal:

European Journal of Applied Physiology

Year:

2010

Language:

english

File:

PDF, 274 KB

english, 2010

9

Adenovirus-mediated Gene Transfer into the NTS in Conscious Rats : A New Approach to Examining the Central Control of Cardiovascular Regulation

YOSHITAKA HIROOKA, KOJI SAKAI, TAKUYA KISHI, AKIRA TAKESHITA

Journal:

Annals of the New York Academy of Sciences

Year:

2001

Language:

english

File:

PDF, 3.93 MB

english, 2001

10

Amlodipine-Induced Reduction of Oxidative Stress in the Brain Is Associated with Sympatho-Inhibitory Effects in Stroke-Prone Spontaneously Hypertensive Rats

HIROOKA, Yoshitaka, KIMURA, Yoshikuni, NOZOE, Masatsugu, SAGARA, Yoji, ITO, Koji, SUNAGAWA, Kenji

Journal:

Hypertension Research

Year:

2006

Language:

english

File:

PDF, 537 KB

english, 2006

11

Adenovirus-mediated gene transfer into the brain stem to examine cardiovascular function: role of nitric oxide and Rho-kinase

Yoshitaka Hirooka

Journal:

Progress in Biophysics and Molecular Biology

Year:

2004

Language:

english

File:

PDF, 487 KB

english, 2004

12

Effect of pravastatin on endothelial function in patients with coronary artery disease (cholesterol-independent effect of pravastatin)

Akihiro Masumoto, Yoshitaka Hirooka, Kiyoshi Hironaga, Kenichi Eshima, Soko Setoguchi, Kensuke Egashira, Akira Takeshita

Journal:

The American Journal of Cardiology

Year:

2001

Language:

english

File:

PDF, 97 KB

english, 2001

13

Role of angiotensin II receptor subtypes in mediating the sympathoexcitatory effects of exogenous and endogenous angiotensin peptides in the rostral ventrolateral medulla of the rabbit

Yoshitaka Hirooka, Patrick D Potts, Roger A.L Dampney

Journal:

Year:

1997

Language:

english

File:

PDF, 121 KB

english, 1997

14

Evaluation of the severity of mitral regurgitation by transesophageal Doppler flow echocardiography

Jun-Ichi Sadoshima, Samon Koyanagi, Masaru Sugimachi, Yoshitaka Hirooka, Akira Takeshita

Journal:

American Heart Journal

Year:

1992

Language:

english

File:

PDF, 2.83 MB

english, 1992

15

Right-to-left shunt across atrial septal defect related to tricuspid regurgitation: Assessment by transesophageal Doppler echocardiography

Hisashi Kai, Samon Koyanagi, Yoshitaka Hirooka, Masaru Sugimachi, Jun-Ichi Sadoshima, Satoshi Suzuki, Akira Takeshita

Journal:

American Heart Journal

Year:

1994

Language:

english

File:

PDF, 3.02 MB

english, 1994

16

Evidence against the central nervous system being involved in altered reflex control of sympathetic nerve activity by atrial natriuretic peptide

Satoshi Suzuki, Akira Takeshita, Tsutomu Imaizumi, Yoshitaka Hirooka, Megumu Yoshida, Motoomi Nakamura

Journal:

Year:

1989

Language:

english

File:

PDF, 479 KB

english, 1989

17

Localized gene transfer and its application for the study of central cardiovascular control

Yoshitaka Hirooka

Journal:

Autonomic Neuroscience

Year:

2006

Language:

english

File:

PDF, 436 KB

english, 2006

18

Activation of Rho-kinase in the brainstem enhances sympathetic drive in mice with heart failure

Koji Ito, Yoshikuni Kimura, Yoshitaka Hirooka, Yoji Sagara, Kenji Sunagawa

Journal:

Autonomic Neuroscience

Year:

2008

Language:

english

File:

PDF, 523 KB

english, 2008

19

Role of reactive oxygen species in brainstem in neural mechanisms of hypertension

Yoshitaka Hirooka

Journal:

Autonomic Neuroscience

Year:

2008

Language:

english

File:

PDF, 274 KB

english, 2008

20

Dysregulation of Brain MR-ENaCs Pathway Contributes to the Acquisition of Brain Na Sensitivity in Mice With LVH

Koji Ito, Yoshitaka Hirooka, Kenji Sunagawa

Journal:

Journal of Cardiac Failure

Year:

2009

Language:

english

File:

PDF, 58 KB

english, 2009

21

Enhanced Aldosterone Synthesis and Insufficient Activation of cyp2c2-EET in the Brain Contributes to the Increased Na-sensitivity in Pressure-Overload Model

Koji Ito, Yoshitaka Hirooka, Kenji Sunagawa

Journal:

Journal of Cardiac Failure

Year:

2010

Language:

english

File:

PDF, 38 KB

english, 2010

22

AT1 Receptor Activated by Toll Like Receptor 4 in the Brainstem Causes Sympathoexcitation in Mice With Heart Failure

Kiyohiro Ogawa, Yoshitaka Hirooka, Takuya Kishi, Kenji Sunagawa

Journal:

Journal of Cardiac Failure

Year:

2010

Language:

english

File:

PDF, 57 KB

english, 2010

23

The Role of Central NRG-1/ErbB Signaling in Heart Failure of Pressure Overload Model

Ryuichi Matsukawa, Yoshitaka Hirooka, Koji Ito, Kenji Sunagawa

Journal:

Journal of Cardiac Failure

Year:

2011

Language:

english

File:

PDF, 41 KB

english, 2011

24

Vascular responses to fear-induced stress in humans

Naoyuki Hayashi, Nami Someya, Toru Maruyama, Yoshitaka Hirooka, Masako Yamaoka Endo, Yoshiyuki Fukuba

Journal:

Physiology & Behavior

Year:

2009

Language:

english

File:

PDF, 564 KB

english, 2009

25

Ethyl icosapentate (omega-3 fatty acid) causes accumulation of lipids in skeletal muscle but suppresses insulin resistance in OLETF rats

Masataka Kusunoki, Kazuhiko Tsutsumi, Tsutomu Hara, Hitoshi Ogawa, Takao Nakamura, Tetsuo Miyata, Fumihiko Sakakibara, Yoshitaka Fukuzawa, Takashi Suga, Koichi Kato, Yoshitumi Hirooka, Yutaka Nakaya

Journal:

Year:

2003

Language:

english

File:

PDF, 109 KB

english, 2003

26

Endogenous nitric oxide prevents myocardial ischemia in patients with hypertension and left ventricular hypertrophy

Masahiro Mohri, Toshihiro Ichiki, Yoshitaka Hirooka, Akira Takeshita

Journal:

American Heart Journal

Year:

2002

Language:

english

File:

PDF, 119 KB

english, 2002

27

Exercise Training Causes Sympathoinhibition Through Antioxidant Effect in the Rostral Ventrolateral Medulla of Hypertensive Rats

Kishi, Takuya, Hirooka, Yoshitaka, Katsuki, Masato, Ogawa, Kiyohiro, Shinohara, Keisuke, Isegawa, Kengo, Sunagawa, Kenji

Journal:

Clinical and Experimental Hypertension

Year:

2012

Language:

english

File:

PDF, 280 KB

english, 2012

28

Mechanisms involved in aortic baroreceptor excitation during drug-induced aortic pressure elevation in intact rabbits

Yoshitaka Hirooka, Tsutomu Imaizumi, Masaru Sugimachi, Akira Takeshita

Journal:

Journal of the Autonomic Nervous System

Year:

1992

Language:

english

File:

PDF, 556 KB

english, 1992

29

Postganglionic sympathetic nerve discharges can contain both central and pulse-related oscillations simultaneously in rabbits

Shin-ichi Ando, Tsutomu Imaizumi, Seiki Harada, Satoshi Suzuki, Masaru Sugimachi, Kenji Sunagawa, Yoshitaka Hirooka, Akira Takeshita

Journal:

Journal of the Autonomic Nervous System

Year:

1994

Language:

english

File:

PDF, 825 KB

english, 1994

30

Effect of l-arginine on acetylcholine-induced endothelium-dependent vasodilation differs between the coronary and forearm vasculatures in humans

Yoshitaka Hirooka, Kensuke Egashira, Tsutomu Imaizumi, Tatsuya Tagawa, Hisashi Kai, Masaru Sugimachi, Akira Takeshita

Journal:

Journal of the American College of Cardiology

Year:

1994

Language:

english

File:

PDF, 1.13 MB

english, 1994

31

Rho-Kinase Inhibitor Improves Increased Vascular Resistance and Impaired Vasodilation of the Forearm in Patients with Heart Failure

Takuya Kishi, Yoshitaka Hirooka, Akihiro Masumoto, Kousuke Inokuchi, Koji Ito, Tatsuya Tagawa, Hiroaki Shimokawa, Akira Takeshita, Kenji Sunagawa

Journal:

Journal of Cardiac Failure

Year:

2005

Language:

english

File:

PDF, 17 KB

english, 2005

32

Roles of Inflammation in the Exaggeration of Hypertensive Cardiac Damages Induced by Large Blood Pressure Variability

Hiroshi Kudo, Hisashi Kai, Narimasa Takayama, Takahiro Mori, Yusuke Sugi, Kiyoko Takemiya, Yoshitaka Hirooka, Hideo Yasukawa, Tsutomu Imaizumi

Journal:

Journal of Cardiac Failure

Year:

2005

Language:

english

File:

PDF, 17 KB

english, 2005

33

Vagal Nerve Stimulation Acutely Decreases the Generation of Free Radicals in Failing Myocardium

Takaki Tsutsumi, Tomomi Ide, Mayumi Yamato, Atsunori Kamiya, Hideo Utsumi, Yoshitaka Hirooka, Kenji Sunagawa

Journal:

Journal of Cardiac Failure

Year:

2006

Language:

english

File:

PDF, 48 KB

english, 2006

34

Activation of Brain AT1 Receptors Caused by Increased Circulating Angiotensin II is Critically Involved in Left Ventricular Diastolic Dysfunction

Keisuke Shinohara, Yoshitaka Hirooka, Takuya Kishi, Kenji Sunagawa

Journal:

Journal of Cardiac Failure

Year:

2012

Language:

english

File:

PDF, 62 KB

english, 2012

35

Brain Tumor Necrosis Factor-α Augments Sympathoexcitation and Left Ventricular Remodeling of Heart Failure via Dysfunction of Nrf2-mediated Anti-apoptosis in Astrocyte

Takuya Kishi, Yoshitaka Hirooka, Kenji Sunagawa

Journal:

Journal of Cardiac Failure

Year:

2012

Language:

english

File:

PDF, 108 KB

english, 2012

36

Role of endothelium in control of forearm bloodflow in patients with heart failure

Akira Takeshita, Yoshitaka Hirooka, Tsutomu Imaizumi

Journal:

Journal of Cardiac Failure

Year:

1996

Language:

english

File:

PDF, 623 KB

english, 1996

37

Endogenous angiotensin in the nucleus tractus solitarii is involved in the increased sympathetic nerve activity in the rats with heart failure via AT1 receptors

Hideaki Shigematsu, Yoshitaka Hirooka, Tatsuya Tagawa, Shin-ichi Ando, Isamu Matsuo, Kenichi Eshima, Akira Takeshita

Journal:

Journal of Cardiac Failure

Year:

1998

Language:

english

File:

PDF, 152 KB

english, 1998

38

Tetrahydrobiopterin improves impaired endothelium-dependent vasodilation in patients with chronic heart failure

Soko Setoguchi, Yoshitaka Hirooka, Kenichi Eshima, Tomomi Ide, Hiroyuki Tsutsui, Akira Takeshita

Journal:

Journal of Cardiac Failure

Year:

1999

Language:

english

File:

PDF, 137 KB

english, 1999

39

Oxidative stress in the cardiovascular center has a pivotal role in the sympathetic activation in hypertension

Hirooka, Yoshitaka

Journal:

Hypertension Research

Year:

2011

Language:

english

File:

PDF, 313 KB

english, 2011

40

Chronic treatment with novel endothelin receptor antagonist macitentan improved severe pulmonary arterial hypertension in rats

Abe, Kohtaro, Kunita, Mutsumi, Hirooka, Yoshitaka, Kuwabara, Yukimitsu, Hirano, Katsuya, Sunagawa, Kenji

Journal:

Year:

2013

Language:

english

File:

PDF, 46 KB

english, 2013

41

Announcement

Abe, Kohtaro, Kunita, Mutsumi, Hirooka, Yoshitaka, Kuwabara, Yukimitsu, Hirano, Katsuya, Sunagawa, Kenji

Journal:

Diabetes Research and Clinical Practice

Year:

1985

File:

PDF, 25 KB

1985

42

Brain Angiotensin II Type 1 Receptors in Astrocytes, not Neurons, Are Upregulated in Mice With Myocardial Infarction-Induced Heart Failure

Isegawa, Kengo, Hirooka, Yoshitaka, Kishi, Takuya, Sunagawa, Kenji

Journal:

Journal of Cardiac Failure

Year:

2013

Language:

english

File:

PDF, 45 KB

english, 2013

43

Targeted Deletion of Astrocyte-specific Angiotensin II Type 1 Receptor Strikingly Improves Prognosis of Myocardial Infarction-induced Heart Failure

Isegawa, Kengo, Hirooka, Yoshitaka, Kishi, Takuya, Sunagawa, Kenji

Journal:

Journal of Cardiac Failure

Year:

2014

Language:

english

File:

PDF, 209 KB

english, 2014

44

Atorvastatin Reduces Oxidative Stress in the Rostral Ventrolateral Medulla of Stroke-Prone Spontaneously Hypertensive Rats

Kishi, Takuya, Hirooka, Yoshitaka, Shimokawa, Hiroaki, Takeshita, Akira, Sunagawa, Kenji

Journal:

Clinical and Experimental Hypertension

Year:

2008

Language:

english

File:

PDF, 150 KB

english, 2008

45

Therapeutic Potential of Rho-Kinase Inhibitors in Cardiovascular Diseases

Dr Yoshitaka Hirooka,Hiroaki Shimokawa

Journal:

American Journal of Cardiovascular Drugs

Year:

2005

Language:

english

File:

PDF, 144 KB

english, 2005

46

Combination Therapy of Olmesartan and Azelnidipine Inhibits Sympathetic Activity Associated with Reducing Oxidative Stress in the Brain of Hypertensive Rats

Shinohara, Keisuke, Hirooka, Yoshitaka, Ogawa, Kiyohiro, Kishi, Takuya, Yasukawa, Keiji, Utsumi, Hideo, Sunagawa, Kenji

Journal:

Clinical and Experimental Hypertension

Year:

2012

Language:

english

File:

PDF, 316 KB

english, 2012

47

Benefit of azilsartan on blood pressure elevation around rest-to-active phase in spontaneously hypertensive rats

Isegawa, Kengo, Hirooka, Yoshitaka, Kishi, Takuya, Yasukawa, Keiji, Utsumi, Hideo, Sunagawa, Kenji

Journal:

Clinical and Experimental Hypertension

Year:

2015

Language:

english

File:

PDF, 306 KB

english, 2015

48

Corticosterone-activated mineralocorticoid receptor contributes to salt-induced sympathoexcitation in pressure overload mice

Ito, Koji, Hirooka, Yoshitaka, Sunagawa, Kenji

Journal:

Clinical and Experimental Hypertension

Year:

2014

Language:

english

File:

PDF, 577 KB

english, 2014

49

Long-Acting Calcium Channel Blocker, Azelnidipine, Increases Endothelial Nitric Oxide Synthase in the Brain and Inhibits Sympathetic Nerve Activity

Kimura, Yoshikuni, Hirooka, Yoshitaka, Sagara, Yoji, Sunagawa, Kenji

Journal:

Clinical and Experimental Hypertension

Year:

2007

Language:

english

File:

PDF, 116 KB

english, 2007

50

Effects of Valsartan or Amlodipine on Endothelial Function and Oxidative Stress after One Year Follow-up in Patients with Essential Hypertension

Hirooka, Yoshitaka, Kimura, Yoshikuni, Sagara, Yoji, Ito, Koji, Sunagawa, Kenji

Journal:

Clinical and Experimental Hypertension

Year:

2008

Language:

english

File:

PDF, 259 KB

english, 2008

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